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Preferencia de vardenafilo vs Sildenafilo en pacientes españoles con disfunción eréctil: resultados procedentes de un estudio multicéntrico internacional
vardenafil vs sildenafil patient preference in spanish men with erectile dysfunction: results from an international multicentric study
L. Rodríguez Vela * , E. Lledó García ** , O. Rajmil *** , D. Mo **** , A. Cassinello ***** , 1 , J. Casariego *****
Comparar la preferencia por sildenafilo vs. vardenafilo, y por sus instrucciones de administración en una cohorte de pacientes españoles con disfunción eréctil (DE)
64 pacientes españoles participantes en un estudio multicéntrico, de 2 periodos, cruzado y doble-ciego (con 265 pacientes en total) se distribuyeron aleatoriamente para recibir sildenafilo (50 mg) o vardenafilo (20 mg) a demanda durante 12 semanas, tras lo cual se cruzaron para recibir el régimen alternativo otras 12 semanas, para valorar la preferencia por uno de los dos tratamientos en una fase de extensión del estudio. Igualmente, para valorar la preferencia por las respectivas instrucciones de administración, 13 pacientes se distribuyeron en 2 brazos de tratamiento con vardenafilo 20 mg: uno con las instrucciones de administración de sildenafilo (S) y otro con las de vardenafilo (T)
De los 56 pacientes que finalizaron el estudio, un 70% eligieron recibir tratamiento con vardenafilo frente a sildenafilo (30%) en la extensión (p < 0,01). Igualmente, un 73% de los 13 que valoraron las instrucciones de administración de ambos fármacos prefirieron las instrucciones de T (p>0,05). La preferencia no varió con la edad, enfermedades concomitantes o uso previo de sildenafilo
En este estudio, aproximadamente 7 de cada 10 pacientes prefirieron vardenafilo y sus instrucciones de administración frente a sildenafilo, como tratamiento para su DE
To compare patient preference for sildenafil citrate (sildenafil) vs. vardenafil and for their respective dosing instructions in a cohort of Spanish patients with erectile dysfunction (ED)
Sixty four Spanish patients from a multicenter, two period, cross-over, double-blind study (265 patients enrolled in total) were randomized to receive on-demand sildenafil 50 mg or vardenafil 20 mg for 12 weeks and afterwards were crossed over to the alternate regimen for another 12 weeks to assess drug preference in an extension period of the study. Similarly, to evaluate preference for their respective dosing instructions, 30 patients were randomized to one of the 2 arms treated with vardenafil: one with sildenafil (S) dosing instructions and the other with vardenafil (T) dosing instructions
Seventy percent of 56 patients completing the study chose to receive vardenafil treatment versus sildenafil treatment (30%) in the extension period (p < 0.01). Correspondingly, 73% of 13 evaluating each drug dosing instructions preferred T dosing instructions (p>0.05). Preference did not vary with age, concomitant diseases and previous use of sildenafil
In this study, 7 out of 10 patients preferred vardenafil and its dosing instructions to sildenafil, for the treatment of their ED
To compare patient preference for sildenafil citrate (sildenafil) vs. vardenafil and for their respective dosing instructions in a cohort of Spanish patients with erectile dysfunction (ED)
vardenafilo Lilly
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Sixty four Spanish patients from a multicenter, two period, cross-over, double-blind study (265 patients enrolled in total) were randomized to receive on-demand sildenafil 50 mg or vardenafil 20 mg for 12 weeks and afterwards were crossed over to the alternate regimen for another 12 weeks to assess drug preference in an extension period of the study. Similarly, to evaluate preference for their respective dosing instructions, 30 patients were randomized to one of the 2 arms treated with vardenafil: one with sildenafil (S) dosing instructions and the other with vardenafil (T) dosing instructions
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Sixty four Spanish patients from a multicenter, two period, cross-over, double-blind study 265 patients enrolled in total were randomized to receive on-demand sildenafil 50 mg or vardenafil 20 mg for 12 weeks and afterwards were crossed over to the alternate regimen for another 12 weeks to assess drug preference in an extension period of the study.
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2023-05-14 07:33:15