vardenafila Spray

A randomized single-center study to compare the efficacy and tolerability of vardenafil once daily plus lidocaine anesthetic spray on premature ejaculation


A randomized single-center study to compare the efficacy and tolerability of vardenafil once daily plus lidocaine anesthetic spray on premature ejaculation

OBJECTIVE: The use of topical local anesthetics in the form of creams, gel or spray is the oldest method of retarding ejaculation. However, several studies have suggested that phosphodiesterase type 5 inhibitors (5-PDEiS) show a potential therapeutic use in the treatment of premature ejaculation (PE).

The aim of this study was to compare the efficacy and tolerability of vardenafil-only, vardenafil plus local anesthetic spray (lidocaine), and topical lidocaine spray-only before intercourse on the intravaginal ejaculatory latency time (IELT) of patients with lifelong PE.

PATIENTS AND METHODS: The study included 78 men in stable heterosexual, monogamous relationships (of ≥3 months) who were diagnosed with lifelong PE. The patients were divided into three groups: G1: 25 patients who received lidocaine spray 10 g/100 ml at 5 min before intercourse; G2: 27 patients who received vardenafil 5 mg once daily; G3: 26 patients who treated with vardenafil once daily plus lidocaine spray before planned sexual activity. The treatments were continued for up to three months in all groups. Moreover, the quality of their sexual attempts was rated on a 5-point scale. Follow-up was made at 1-month and 3-month.

RESULTS: Not statistically significant differences emerged between the three groups at baseline. Mean ejaculatory latency time at the 3-month follow-up in G1, G2 and G3 was 3.7±1.3, 3.4±1.5, 5.6±1.7 (p<0.001). Mean satisfaction score was at the 3-month follow-up in G1: 2.8±1.4, in G2: 2.9±1.8, and G3: 3.7±1.5 (p<0.002). None of the patients withdrew from the study because of these adverse events.

CONCLUSIONS: This study demonstrates that vardenafil used daily has a role on treatment in lifelong PE. This action is valid when combined strategically to the synergistic action of lidocaine spray applied before intercourse increasing significantly the mean IELT.

To cite this article

L. Dell’Atti, A.B. Galosi, C. Ippolito
A randomized single-center study to compare the efficacy and tolerability of vardenafil once daily plus lidocaine anesthetic spray on premature ejaculation

Eur Rev Med Pharmacol Sci
Year: 2017
Vol. 21 - N. 5
Pages: 1036-1040


The aim of this study was to compare the efficacy and tolerability of vardenafil-only, vardenafil plus local anesthetic spray (lidocaine), and topical lidocaine spray-only before intercourse on the intravaginal ejaculatory latency time (IELT) of patients with lifelong PE.


A randomized single-center study to compare the efficacy and tolerability of vardenafil once daily plus lidocaine anesthetic spray on premature ejaculation

OBJECTIVE: The use of topical local anesthetics in the form of creams, gel or spray is the oldest method of retarding ejaculation. However, several studies have suggested that phosphodiesterase type 5 inhibitors (5-PDEiS) show a potential therapeutic use in the treatment of premature ejaculation (PE).

The aim of this study was to compare the efficacy and tolerability of vardenafil-only, vardenafil plus local anesthetic spray (lidocaine), and topical lidocaine spray-only before intercourse on the intravaginal ejaculatory latency time (IELT) of patients with lifelong PE.

PATIENTS AND METHODS: The study included 78 men in stable heterosexual, monogamous relationships (of ≥3 months) who were diagnosed with lifelong PE. The patients were divided into three groups: G1: 25 patients who received lidocaine spray 10 g/100 ml at 5 min before intercourse; G2: 27 patients who received vardenafil 5 mg once daily; G3: 26 patients who treated with vardenafil once daily plus lidocaine spray before planned sexual activity. The treatments were continued for up to three months in all groups. Moreover, the quality of their sexual attempts was rated on a 5-point scale. Follow-up was made at 1-month and 3-month.

RESULTS: Not statistically significant differences emerged between the three groups at baseline. Mean ejaculatory latency time at the 3-month follow-up in G1, G2 and G3 was 3.7±1.3, 3.4±1.5, 5.6±1.7 (p<0.001). Mean satisfaction score was at the 3-month follow-up in G1: 2.8±1.4, in G2: 2.9±1.8, and G3: 3.7±1.5 (p<0.002). None of the patients withdrew from the study because of these adverse events.

CONCLUSIONS: This study demonstrates that vardenafil used daily has a role on treatment in lifelong PE. This action is valid when combined strategically to the synergistic action of lidocaine spray applied before intercourse increasing significantly the mean IELT.


OBJECTIVE: The use of topical local anesthetics in the form of creams, gel or spray is the oldest method of retarding ejaculation. However, several studies have suggested that phosphodiesterase type 5 inhibitors (5-PDEiS) show a potential therapeutic use in the treatment of premature ejaculation (PE).


To cite this article


The aim of this study was to compare the efficacy and tolerability of vardenafil-only, vardenafil plus local anesthetic spray lidocaine , and topical lidocaine spray-only before intercourse on the intravaginal ejaculatory latency time IELT of patients with lifelong PE.




01.09.2021 16:37:12

2021-09-01 16:37:12

PATIENTS AND METHODS: The study included 78 men in stable heterosexual, monogamous relationships (of ≥3 months) who were diagnosed with lifelong PE. The patients were divided into three groups: G1: 25 patients who received lidocaine spray 10 g/100 ml at 5 min before intercourse; G2: 27 patients who received vardenafil 5 mg once daily; G3: 26 patients who treated with vardenafil once daily plus lidocaine spray before planned sexual activity. The treatments were continued for up to three months in all groups. Moreover, the quality of their sexual attempts was rated on a 5-point scale. Follow-up was made at 1-month and 3-month.

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